Professor Wayne Tilley and his team at the Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide, have been testing a series of existing drugs (already approved for human use but not being used to treat prostate cancer) PLUS potential new drugs (not yet tested in humans) to see which ones show promise in changing a hormone receptor from cancer-promoting to cancer-inhibiting.
The team has now identified an exciting list of known and new drugs to take forward!
“This rapid translation of our work into the clinical arena illustrates the power of finding a new purpose for drugs developed for one disease that may be useful for the treatment of another disease,” Prof Tilley said.
“For the known drugs, we are now working to present the final evidence necessary to design and establish clinical trials to test their efficacy in patients.
“For the potential new drugs, we will now embark on a drug development phase and pre-clinical testing to ensure they have optimal drug properties and are non-toxic before being tested in people.”
This important work has been undertaken with support from Australian Prostate Cancer (APC); and is saving even more lives because it is also being applied to breast cancer in collaboration with Associate Professor Theresa Hickey.
“We have already advanced one known drug candidate for breast cancer. The work related to breast cancer is being considered for publication in a highly esteemed scientific journal and we have commenced a clinical trial. The work related to prostate cancer is being prepared for publication and discussions are underway for clinical trial design,” Prof Tilley said.
“In addition to these clinical outcomes, the project has produced a wealth of new information and data that will be shared with researchers worldwide via publication and deposit of data into public repositories.
“By the end of this project, we aim to have at least three scientific publications describing our work and its results, to have designed at least one clinical trial involving a repurposed drug for breast or prostate cancer, and have at least one new drug enter the drug development pipeline.”
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